Oxygen consumption is decreased in TP treated MDA-MB-435 cells.

<p>OCR and ECAR were measured using the XF 24 Extracellular Flux Analyzer. Addition of TP compounds resulted in a decrease in OCR with a simultaneous increase in ECAR. The observed decrease in OCR was not affected by addition of inhibitors of ATP synthase, uncoupling agents or complex I inhibition. [Port A: TP compound (5 µM), Port B: Oligomycin (0.005 mg/mL), Port C: FCCP (1 µM) Port D: Rotenone (1 µM).