TGF-β isoform shared regulation of allergen-induced sub-epithelial collagen deposition.

<p>Control (A) and OVA sensitised and challenged (B) mouse airways 12 days following final challenge demonstrating allergen-induced increase in sub-epithelial collagen deposition depicted by blue staining of the thickened airway wall using a modified Martius Scarlet Blue stain. Scale bar represents 50 µm. (C) Quantification of the area of collagen staining demonstrating OVA-induced increase in sub-epithelial collagen deposition and its inhibition by treatment with antibodies to TGF-β₁ or -β₂. Each value represents the mean ± SEM of measurements from 7–10 animals per group. **, P<0.001 compared with relative control. ⁺, P<0.02 and ⁺⁺, P<0.01 compared with OVA control groups.