BMP-7 inhibits TGF-β1-induced synthesis of collagen-I by lung fibroblasts.

<p>Mouse lung fibroblasts from control animals (A) were stimulated with TGF-β1 (5 ng/ml) alone or in combination with BMP-7 (30, 100 ou 300 ng/ml) during 18 hours. Mouse lung fibroblasts from asthmatic animals (B) were treated with TGF-β1 (5 ng/ml) alone or in combination with BMP-7 (300 ng/ml). Type I collagen was analyzed by western blot and normalized by β-actin expression. Results are presented as percentage of the control or as arbitrary units. Data are representative of 5 animals in each of 3 independent experiments. *p<0.05 comparing with the control group.