TGF-β isoform specific regulation of allergen-induced sub-epithelial decorin deposition.

<p>Control (A) and OVA sensitised and challenged (B) mouse airways 12 days following final challenge demonstrating allergen-induced increase in sub-epithelial decorin deposition depicted by brown staining of the thickened airway wall by immunohistochemistry. Scale bar represents 50 µm. (C) Quantification of the area of decorin staining demonstrating OVA-induced increase in sub-epithelial decorin deposition and its inhibition by treatment with antibodies to TGF-β₁ but not TGF-β₂. Each value represents the mean ± SEM of measurements from 9–10 animals per group. *, P<0.001 compared with relative control. ⁺, P<0.01 compared with OVA control and not significantly different to the saline anti-TGF-β₁ group.