Chronic allergen exposure induces airway inflammation and remodelling.

<p>Mice were challenged with OVA for up to 18 weeks (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085839#pone-0085839-g001" target="_blank">Figure 1</a>, Protocol A) and analysed for airway inflammation, as determined by (A) BALF cell counts and morphometric quantification of peribronchial inflammation. (B) Airway remodelling was determined by quantification of goblet cell hyperplasia, subepithelial collagen deposition and smooth muscle thickening. Data points represent means ± SEM of n = 6–8 animals per group.