Antibody levels and percent survival of BALB/c and SCID mice following active and/or passive immunization with J8-DT, DT or PBS.

<p>(a) J8-specific serum IgG concentrations in donor BALB/c or recipient SCID mice. Serum samples were collected post-immunization (for donors) or post second administration of J8-DT or DT antiserum (for recipients). J8-specific IgG concentrations in serum of individual mice, are shown, with mean concentration represented as horizontal bars. (b) Protection induced in BALB/c and SCID mice by J8-DT following active (I/Ch) and/or passive immunization (PT/Ch). The mice were challenged with M1 GAS and their survival monitored. Mann-Whitney test was performed to compare the proportions of surviving mice. Significance is represented as * p<0.05 and ** p<0.01.