Induction of anti IgY Abs and IgY treatment in mice with pre-existing anti IgY.

<p>Anti IgY in the sera of mice immunized with normal IgY (IgY immunized), treated once intranasally with PR8-specific IgY 8 hours before (anti PR8 IgY −8 h) or three times after infection (anti PR8 IgY +8, 32, 56 h) (Fig. 4A). Endpoint titers (log₂) were determined by ELISA. Morbidity and mortality of IgY-immunized mice treated with PR8-specific IgY (anti PR8 IgY) before (−6 hr) or after (+6 hr) infection with mouse-adapted PR8 (Fig. 4B). The values are the mean of 5–10 mice in each group.