Metabolic parameters of male GHRKO (KO) and normal (N) mice fed <i>ad libitum</i> (AL) or subjected to 30% calorie restriction (CR) for one year.

<p>Panel (A) shows time-course changes in body weight over a one year period. After one year of CR, all groups were fasted overnight and bodyweight (B), peripheral glucose (C), insulin (D), and calculated homeostatic model of assessment (HOMA, E) were determined. Values with unlike superscripts/letters are significantly different (P<0.05).