<p>The mutants had a smaller skeleton, abnormal skulls with a domed vault (arrowhead) and protruding incisors (small arrow). Kyphosis (large arrow) of the cervical-thoracic spine was also observed in the mutants. Control, <i>R26<sup>floxneoWnt4</sup></i> heterozygote; mutant, <i>R26<sup>floxneoWnt4</sup>; Col2a1-Cre</i>.</p
<p>X-rays of 6 week-old <i>+/+</i> (A, B, C) and <i>Dhe/+</i> (D, E, F) hemisected skulls. Note lowe...
<p>Ventral view of alizarin-red-stained craniofacial skeleton and teeth at 6 dpf (A, B) and dissecte...
<p>(A) Skeletons of 6-day-old control (left) and <i>Twist1<sup>flox/+</sup></i>; <i>Twist2<sup>Cre/+...
<p>Skeleton preparations from 6-week-old <i>R26<sup>floxneoWnt4</sup>; Col2a1-Cre</i> mutants and <i...
<p>A, C, E, G are H & E stained histological sections of <i>R26<sup>floxneoWnt4</sup></i> heterozygo...
<p>(A–E) Alcian blue/Alizarin red staining of (A) elbow joints (lateral view), (B) knee joints (late...
<p>(A–I) Necropsy showed <i>Wdpcp<sup>Cys40</sup></i> neonatal mutants have a wide spectrum of defec...
<p>(A and E) Ectopic tissues were observed above the eyes in the mutants (yellow arrows). (B and F) ...
<p><b>A, B</b>) Upper panels are Alcian Blue/Alizarin Red staining of cartilage and bone skeletal pr...
Twenty-one day old (A) Clcn7WT/WT and (B) Clcn7Flox/Flox mice were sacrificed and then X-ray and μCT...
<p>Alizarin red (bone) and alcian blue (cartilage) stained skeletal preparations of <i>Foxc1<sup>+/+...
<p><b>A,B</b>) In severely affected <i>RockDN;Wnt1-cre</i> embryos at E14.5, the frontonasal bones (...
<p>A) Micro CT scans of the heads of neonates with the indicated genotype. Top row shows a dorsal vi...
<p>(<b>A</b>) Gross morphology of 12-week-old <i>Fgfr3</i> cKO mice with large stature. Femur and ti...
<p>(A) Genotypes of a litter from <i>Fgfr2<sup>+/S252W-neo</sup></i>+<i>EII-Cre</i> by PCR of tail D...
<p>X-rays of 6 week-old <i>+/+</i> (A, B, C) and <i>Dhe/+</i> (D, E, F) hemisected skulls. Note lowe...
<p>Ventral view of alizarin-red-stained craniofacial skeleton and teeth at 6 dpf (A, B) and dissecte...
<p>(A) Skeletons of 6-day-old control (left) and <i>Twist1<sup>flox/+</sup></i>; <i>Twist2<sup>Cre/+...
<p>Skeleton preparations from 6-week-old <i>R26<sup>floxneoWnt4</sup>; Col2a1-Cre</i> mutants and <i...
<p>A, C, E, G are H & E stained histological sections of <i>R26<sup>floxneoWnt4</sup></i> heterozygo...
<p>(A–E) Alcian blue/Alizarin red staining of (A) elbow joints (lateral view), (B) knee joints (late...
<p>(A–I) Necropsy showed <i>Wdpcp<sup>Cys40</sup></i> neonatal mutants have a wide spectrum of defec...
<p>(A and E) Ectopic tissues were observed above the eyes in the mutants (yellow arrows). (B and F) ...
<p><b>A, B</b>) Upper panels are Alcian Blue/Alizarin Red staining of cartilage and bone skeletal pr...
Twenty-one day old (A) Clcn7WT/WT and (B) Clcn7Flox/Flox mice were sacrificed and then X-ray and μCT...
<p>Alizarin red (bone) and alcian blue (cartilage) stained skeletal preparations of <i>Foxc1<sup>+/+...
<p><b>A,B</b>) In severely affected <i>RockDN;Wnt1-cre</i> embryos at E14.5, the frontonasal bones (...
<p>A) Micro CT scans of the heads of neonates with the indicated genotype. Top row shows a dorsal vi...
<p>(<b>A</b>) Gross morphology of 12-week-old <i>Fgfr3</i> cKO mice with large stature. Femur and ti...
<p>(A) Genotypes of a litter from <i>Fgfr2<sup>+/S252W-neo</sup></i>+<i>EII-Cre</i> by PCR of tail D...
<p>X-rays of 6 week-old <i>+/+</i> (A, B, C) and <i>Dhe/+</i> (D, E, F) hemisected skulls. Note lowe...
<p>Ventral view of alizarin-red-stained craniofacial skeleton and teeth at 6 dpf (A, B) and dissecte...
<p>(A) Skeletons of 6-day-old control (left) and <i>Twist1<sup>flox/+</sup></i>; <i>Twist2<sup>Cre/+...