Identification and observation of bone structures in <i>Fgfr2^+/S252W</i> mice.

<p>(A) Genotypes of a litter from <i>Fgfr2^+/S252W-neo</i>+<i>EII-Cre</i> by PCR of tail DNA. Lanes 1 and 4 are mutant mice, showing the mutant allele after neo deletion (520 bp). Lanes 2, 3, 5, 6, and 7 are wild-type mice. (B) Gross appearance of <i>Fgfr2^+/S252W</i> mutant (MT) and wild-type (WT) mice on postnatal day P1. (C) Top view of P14 mice. Note that the mutant mice have a smaller body size, wide-spaced eyes, and an underdeveloped midface. (D) Growth curves demonstrating significant growth retardation in the mutants. (E, F) Photographs and side view radiographs of WT and MT mice at P7 and P28. The mutant mice showed shortened anterior–posterior axes, short limbs, and overriding lower incisors.