Gross morphology and radiographic assessment of skeletal phenotypes in <i>Fgfr3</i> cKO mice.

<p>(<b>A</b>) Gross morphology of 12-week-old <i>Fgfr3</i> cKO mice with large stature. Femur and tibia lengths were determined from X-ray images; their lengths were increased in <i>Fgfr3</i> cKO as compared to Cre-negative mice. Values represent mean ± SD. ***p < 0.001, **p < 0.01 (n = 10). (<b>B</b>) X-ray and Micro-CT images showing subluxation/dislocation of the radial head (asterisks) and arch-like deformation of the radius (arrowheads) in <i>Fgfr3</i> cKO mice. Bony lesions (arrows) in mutants were attached to the distal ulna and radius. (<b>C</b>) Gross morphology and X-ray/micro-CT images of the knee joint of 12-week-old <i>Fgfr3</i> cKO mice after skin removal showing a bony lesion (arrows) contiguous with the proximal tibia affected by knee joint deformity (arrowheads). (<b>D, E</b>) Rib bones showing aberrant radiographic density (D, arrows) and an irregular costal cartilage surface (E, arrows) were observed by X-ray and micro-CT in <i>Fgfr3</i> cKO mice.