Skeletal defects associated with the loss of Hat1.

<p>A) Micro CT scans of the heads of neonates with the indicated genotype. Top row shows a dorsal view and bottom row shows a ventral view. Arrows indicate defects in the nasal cavity (top) and jaw structures (bottom). B) Micro CT scans of Hat1^+/+ and Hat1^−/− neonates (as indicated) showing a dorsal view of the entire animal. C) Acian blue and Alizarin red stained Hat1^+/+ and Hat1^−/− neonates. D) Hat1^+/+ and Hat1^−/− embryos (12.5 dpc) were stained with α-Hat1 antibodies. E) Cross section of the head and neck of 11.5 dpc Hat1^+/+ and (WT) and Hat1^−/− embryos stained with α-Hat1 antibody. 2.5× magnification.