Skeletal defects in <i>Dlg1</i>^<i>-/-</i> mice.

<p>Images of control (A–F) and <i>Dlg1</i>^<i>-/-</i> (G–L) mice are shown. (A, G) Craniofacial morphology of the prenatal embryos at E18.5. <i>Dlg1</i>^<i>-/-</i> mice invariably exhibit craniofacial hypoplasia and cyanosis, and often have open eyelids. (B, H) External surface of the cranial base. The mandibular bone has been removed. (C, I) Maxilla and palatal bone at E18.5. (D, J) Sternum at E18.5. (E, K) Hematoxylin and eosin-stained paraffin sections of the lower part of the sternum at E19.5. (F, L) Skeleton of the forelimb at E17.5.