Flow Cytometry Analysis of BM and Spleen in Mice Transduced with MPLW515L and MPLWT
- Yana Pikman (64256)
- Benjamin H Lee (64257)
- Thomas Mercher (64258)
- Elizabeth McDowell (64259)
- Benjamin L Ebert (64260)
- Maricel Gozo (64261)
- Adam Cuker (64262)
- Gerlinde Wernig (64263)
- Sandra Moore (64264)
- Ilene Galinsky (64265)
- Daniel J DeAngelo (64266)
- Jennifer J Clark (64267)
- Stephanie J Lee (64268)
- Todd R Golub (48571)
- Martha Wadleigh (64269)
- D. Gary Gilliland (64270)
- Ross L Levine (64271)
Publication date
February 2013
DOIAbstract
<div><p>(A) Flow-cytometry analysis of bone marrow cells shows a 4-fold increase in Mac1+/Gr1+ cells and a shift to a more immature erythroid population. There is a 15-fold increase in CD41+ cells in bone marrow expressing MPLW515L compared with MPLWT.</p> <p>(B) Flow-cytometry analysis of spleen cells shows a 10-fold increase in Mac1+/Gr1+ cells in MPLW515L. There is also a shift to a more immature erythroid population in MPLW515L with a greater percentage of CD71+/Ter119- cells. CD41+ cells are increased 30-fold in MPLW515L spleen cells compared with MPLWT spleen cells.</p></div
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