Marginal zone B cells are increased in <i>NIAM^m/m</i> mice.

<p>Flow cytometric analyses of splenic B cell development. Splenic B cells were isolated from young, 6 month old tumor-free wild-type (+/+) and <i>NIAM</i> mutant (m/m) mice (three of each genotype). <b>A</b>. Representative flow cytometry plots of <i>NIAM</i> wild-type versus m/m IgM positive splenocytes. Transitional (CD21^lo/CD23-), follicular (CD21+/CD23+) and marginal zone (CD21^hi/CD23-) B cells are identified. <b>B</b>. Average frequency of follicular (top left), transitional (top right), and marginal zone (bottom left) B cells from mice of the indicated genotypes. Average marginal zone B cell numbers are also shown (bottom right). All p values were calculated using unpaired, two-tailed Student's T tests.