Disturbed B cell development and trafficking in <i>Gnai2</i>^fl/fl<i>mb1-cre</i> and DKO mice.

<p>A. Flow cytometric analysis of bone marrow B cells fractions in the control and mutant mice. Pooled results from analyzing bone marrow from at least 6 mice of each genotype. B. Flow cytometric analysis of lymphocytes and B cell population in the blood of control and mutant mice. Pooled results from analyzing blood from 6 <i>Gnai2</i>^fl/fl, 4 <i>Gnai2 </i>^fl/fl<i>mb1-cre</i>, 4 Gnai3^-/-, and 6 DKO mice. C. Flow cytometric analysis of B cell populations in the peritoneum of control and mutant mice. Same mice as used in part B. D. Flow cytometric analysis of spontaneous GCs in control and mutant mice. Pooled results from analyzing cells prepared from spleens and LNs from 9 <i>Gnai2</i>^fl/fl, 8 <i>Gnai2 </i>^fl/fl<i>mb1-cre</i>, 3 Gnai3^-/-, and 3 DKO mice. Data is mean +/- SEM. Statistical significance determined by 2 way ANOVA. *** p<0.001, ** p<0.01, * p<0.05.