<p>The number in parenthesis indicates the number of mice kept for footpad swelling.</p><p>D-25 is the day after infection while D0 is the time of start of treatment.</p><p>Drugs and their doses were, STR = streptomycin, 150 mg/kg; RIF = rifampin, 10 mg/kg; RPT = rifapentine, 10 mg/kg.</p><p>Treatment was either 5 days a week (5/7) or 7 days a week (7/7).</p
Six weeks after the last vaccination, the mice were challenged by 2 ×106 L. tropica stationary proma...
<p>420 mice were divided into animals that were uninfected (NC-UU) (20 mice) and those that were inf...
<p>Treatment schedule for mice for the <i>in vivo</i> infection model (A) and <i>ex vivo C</i>. <i>d...
<p>Kaplan-Meier curve depicting the percentage of mice free of footpad swelling during 39 weeks of f...
<p>Decrease in the log<sub>10</sub> CFU counts in the footpads of mice treated with, streptomycin+ r...
<p>Mice were randomized after infection with 0.03 ml of an inoculum containing 6.06 log<sub>10</sub>...
<p>Mean CFU count from mouse footpads on the day after infection (Day1), the day of treatment initia...
<p>Time to footpad swelling (or ectopic lesions) in mice treated with either RIF+STR (green circles)...
BALB/c mice were inoculated in their footpad with L. major. After 21 days, mice were treated i.p. wi...
<p><b>(A) Footpad swelling</b>. After infection of both hind footpads, treatment began when swelling...
<p>Due to animal welfare reasons, mice were sacrificed early as explained in text.</p><p>D, day; w, ...
<p>After infection in the right hind footpad (RHFP), grade 1 swelling was first detected at 5 weeks....
<p>The mice were treated with RIF (red), STR (green) and CLR (blue) alone. Untreated (black). (A, D,...
<p>In Experiment I, four Δ<i>dbpAB</i>/<i>dbpAB</i> (group 2), eight Δ<i>dbpAB</i>/<i>dbpA</i> (grou...
<p>Beginning 11 days post-infection, mice received monotherapy with different doses of RIF (red), ST...
Six weeks after the last vaccination, the mice were challenged by 2 ×106 L. tropica stationary proma...
<p>420 mice were divided into animals that were uninfected (NC-UU) (20 mice) and those that were inf...
<p>Treatment schedule for mice for the <i>in vivo</i> infection model (A) and <i>ex vivo C</i>. <i>d...
<p>Kaplan-Meier curve depicting the percentage of mice free of footpad swelling during 39 weeks of f...
<p>Decrease in the log<sub>10</sub> CFU counts in the footpads of mice treated with, streptomycin+ r...
<p>Mice were randomized after infection with 0.03 ml of an inoculum containing 6.06 log<sub>10</sub>...
<p>Mean CFU count from mouse footpads on the day after infection (Day1), the day of treatment initia...
<p>Time to footpad swelling (or ectopic lesions) in mice treated with either RIF+STR (green circles)...
BALB/c mice were inoculated in their footpad with L. major. After 21 days, mice were treated i.p. wi...
<p><b>(A) Footpad swelling</b>. After infection of both hind footpads, treatment began when swelling...
<p>Due to animal welfare reasons, mice were sacrificed early as explained in text.</p><p>D, day; w, ...
<p>After infection in the right hind footpad (RHFP), grade 1 swelling was first detected at 5 weeks....
<p>The mice were treated with RIF (red), STR (green) and CLR (blue) alone. Untreated (black). (A, D,...
<p>In Experiment I, four Δ<i>dbpAB</i>/<i>dbpAB</i> (group 2), eight Δ<i>dbpAB</i>/<i>dbpA</i> (grou...
<p>Beginning 11 days post-infection, mice received monotherapy with different doses of RIF (red), ST...
Six weeks after the last vaccination, the mice were challenged by 2 ×106 L. tropica stationary proma...
<p>420 mice were divided into animals that were uninfected (NC-UU) (20 mice) and those that were inf...
<p>Treatment schedule for mice for the <i>in vivo</i> infection model (A) and <i>ex vivo C</i>. <i>d...