Original experimental scheme to compare activities of RIF+STR, RIF+ CLR, RIF+CFZ and CFZ alone in <i>M</i>. <i>ulcerans</i>-infected footpads of BALB/c mice.

<p>Due to animal welfare reasons, mice were sacrificed early as explained in text.</p><p>D, day; w, week; CFU, colony forming units; RIF, rifampin, 10mg/kg; STR, streptomycin, 150mg/kg; CLR, clarithromycin 100mg/kg; CFZ, clofazimine 25mg/kg; CLR and CFZ are given one hour after RIF to prevent adverse pharmacokinetic interactions [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003823#pntd.0003823.ref030" target="_blank">30</a>].</p><p>Original experimental scheme to compare activities of RIF+STR, RIF+ CLR, RIF+CFZ and CFZ alone in <i>M</i>. <i>ulcerans</i>-infected footpads of BALB/c mice.