Expression profiles of genes affected by the WT Nig06 and the ΔF2 Nig06 in lungs of mice at 2 days pi.

<p>Left part of the figure represents a scatterplot comparing normalized expression values in WT-infected and ΔF2-infected mice of a subset of highly differentially expressed genes. A difference of 1 between the normalized expression values was defined as the cutoff for a differentially regulated gene. Several genes annotated by “Gene Ontology” as implicated in cell death are highlighted in purple. Genes induced in each of specific conditions were then selected and represented in the right part of the figure as a heat map. For each gene, the data presented are the average expression levels at day 2 pi and were calculated from replicate RNA samples prepared from 3 individual mice and analyzed on independent microarrays. Genes shown in red are up-regulated and those shown in blue are down-regulated in infected mice compared to mock-infected mice. Data are expressed in Log base 2 ratio. Examples of genes with details on the cellular functions are indicated.