119 genes are significantly highly expressed in lungs of progressor DO mice, compared to controller and non-infected DO mice.

Microarray gene expression profiling identified a set of 119 genes whose expression changed significantly across all groups (moderated ANOVA FDR q 2-fold in progressor DO mice (n = 10; dark brown) relative to both non-infected DO mice (n = 5; gray) and controller DO mice (n = 22; tan). Rows and columns correspond to genes and individual DO mice, respectively. The number of days from the start of the experiment to the euthanasia of each animal is shown below each column. Hierarchical clustering was performed across all rows (left side of Figure) and was also performed separately within each group (top of Figure). The expression values for each gene were z-normalized to a mean of zero and standard deviation of one across all samples in each row; blue, white, and red indicate z-scores of ≤ -2, 0, and ≥ +2, respectively.