Lung transcriptome comparison of mutant versus wild type animals following OVA challenge.

<p>(A) Summarized heat map of genes regulated after OVA challenge in all three mutant mouse lines compared to the respective challenged control littermates. Genes with similar expression patterns are grouped together (A to G). Color code indicates the mean fold changes of the respective genes in one group for each OVA challenged mutant mouse compared to the mean of the corresponding challenged wild type littermates. Orange represents up- and blue down-regulation in the mutant mice. The column “# genes” displays the number of genes that are included in each gene group A to G (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0134503#pone.0134503.s003" target="_blank">S2D Fig</a> shows the corresponding data for individual genes). (B) Venn diagram representing the overlap of gene regulation. (C) Summarized heat map of overlapping gene expression in at least 2 of the 3 mutant mouse lines. Grey boxes indicate that there is no significant regulation of these genes in the respective mutant mouse lines (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0134503#pone.0134503.s003" target="_blank">S2E Fig</a> shows the data for individual genes of this panel).