CD44KO mice are protected against HFD-induced insulin resistance and glucose intolerance.

<p>A) Glucose tolerance test (GTT) and insulin tolerance test (ITT) were analyzed in WT and CD44KO mice fed an HFD for 6 weeks, 12 weeks, or 21 weeks (n = 6–8 mice for each group). Blood glucose levels were analyzed every 20 min for up to 2 hrs after glucose or insulin injection, for GTT or ITT respectively. B) Blood insulin levels were analyzed in WT and CD44KO mice fed a HFD for 21 weeks (WT, n = 7; CD44KO, n = 8). Data represent mean±SEM. *p<0.05, **p<0.01, ***p<0.001.