Histology examination and liver enzymes from DENV-infected mice treated once with 7.5% NaCl at day 6 post-infection.

<p>Groups of 8–9 week-old AG129 mice were left uninfected or were sc infected with D2Y98P-PP1 virus and at day 6 pi., they were treated with a single bolus (iv; 4 mL/kg body weight) of 7.5% NaCl (HTS) or PBS as indicated. At the indicated time points post-infection, the animals were euthanized and their liver (A), intestines (B) and brain (C) were harvested, fixed and processed for H&E staining. Observations were made at x200 (A, B) and x400 (C) magnification. Representative sections from 3 individual mice are shown. (D) Levels of serum alanine (ALT) and aspartate (AST) transaminases were monitored over time post-infection upon treatment with HTS or PBS as indicated. Results are expressed as the mean ± SD of five individual mice per group per time point.