Histological changes in liver upon DENV-2 infection in mice.

<p>WT or KO mice were infected i.p. with 10 LD₅₀ of DENV-2 and then sacrificed at day 6 for tissue samples. Hematoxylin & Eosin stained liver sections from non-infected and DENV-2 infected WT, CCR1^–/–, CCR2^–/– and CCR4^–/– mice, showing different degrees of congestion, hemorrhage, hepatocyte degeneration and necrosis. Each slide presented in the panel is representative of at least 10 different fields (n = 5–6 mice). Magnification: 400X.