SB203580 treatment reduces caspase 9 expression.

<p>Mice were infected with 4 × 10⁵ FFU/ml of DENV and treated with 2%DMSO (v/v) or SB203580 dissolved in 2%DMSO. The control (uninfected) group was treated with 2%DMSO (v/v) alone. Treatments were given 1 h before and after DENV infection and again at 24 h after infection. On day 7 after infection, the liver tissues were collected, and the proteins were extracted for western blotting analysis using antibodies directed against the pro and cleaved forms of (A) caspase 9. The results shown are representative of three independent experiments with three mice (n = 3) from each group. A densitometry analysis using the ImageJ software is shown in (B).