Humoral immune responses elicited by MVA-B and MVA-B deletion mutants against HIV-1 gp120 protein.

<p>Serum was collected from individual mouse immunized with DNA-B/MVA-B, DNA-B/MVA-B ΔC6L or DNA-B/MVA-B ΔC6L/K7R or DNA-φ/MVA-WT (n = 4), 10 days (left panel) or 52 days (right panel) after the last immunization. Levels of gp120-specific IgG binding antibodies were measured by ELISA. Titers represent the last dilution of the serum that signals 3-fold higher than signals obtained with the serum of naïve mice. The horizontal bar represents the mean antibodies titer for each group. Each dot represents data obtained from one mouse. Data are from one experiment representative of three experiments.