<i>Sigirr −/−</i> mice are highly susceptible to enteric infection.

<p>(A) <i>Sigirr −/−</i> mice were heavily colonized by 100× lower dose (LD) of <i>C. rodentium</i> by D2 pi. By D10 pi, <i>Sigirr −/−</i> mice carried 1000× heavier (B) pathogen burdens and developed severe mucosal damage compared to WT mice. (C) WT and <i>Sigirr −/−</i> mice infected by <i>S.</i> Typhimurium without streptomycin pre-treatment. By D7 pi, <i>Sigirr −/−</i> mice were heavily colonized and underwent extensive cecal injury. Pathogen counts represent mucosal associated bacteria. Results are pooled from 2–3 independent infections with n = 3 per group. Error bars = SEM, (Two-way ANOVA (Figure A), Student t test (Figures B and C), *P<0.05, **P<0.01)). Histological images were taken at 100× magnification.