Colitis severity is more pronounced in PPARγVillinCre⁺ mice than in wild-type mice.

<p>Sections of colon from mock- or S. Typhimurium-infected wild-type (C57BL/6) and PPARγVillinCre⁺ mice were stained with hematoxylin and eosin (6 mice per group). (A and B) Wild-type mice mock-infected. (C and D) Wild-type mice infected with S. Typhimurium. PPARγVillinCre− mice mock-infected (E and F), or infected with S. Typhimurium (G and H). PPARγVillinCre⁺ mice mock-infected (I and J), or infected with S. Typhimurium (K and L). All scale bars are 100 µm. Pathology scoring was performed for neutrophil infiltration (M). (N) Myeloperoxidase (MPO) activity in colonic extracts of mice, measured per mg of total protein. In panels M and N, mock (Con)- or S. Typhimurium (Sal)-infected PPARγVillinCre⁺ (Cre⁺) or littermate control PPARγVillinCre− (Cre−) mice were examined. Error bars = ±standard error of the mean. **p<0.01.