Mice depleted of CXCL9 have greater <i>C</i>. rodentium-induced pathology.

<p><b>(A)</b> Rag1^-/- mice were infected with <i>C</i>. <i>rodentium</i> and administered IgG control antibody or anti-CXCL9 antibody. Representative histopathology images (200x) of the distal colon are shown from animals infected for 10 days. <b>(B)</b> Quantification of pathology in colon. Data is pooled from two experiments, n = 6 per group. <b>(C)</b> Localization of <i>C</i>. <i>rodentium</i> in Rag1^-/- mouse colon by immunohistochemistry. Mice were infected with <i>C</i>. <i>rodentium</i> for 10 days. Images (200x) are representative of two separate experiments, n = 6 per group. (<b>D</b>) Quantification of crypt invasion by <i>C</i>. <i>rodentium</i> in Rag1^-/- mice. Data are the means with standard errors. <b>(E)</b> Localization of <i>C</i>. <i>rodentium</i> in the distal colon in C57BL/6 mice and IFN-γ^-/- mice by immunohistochemistry. Mice were assessed on day 10 after <i>C</i>. <i>rodentium</i> infection. Images (200x) are representative of two separate experiments, n = 5 per group. (<b>F</b>) Quantification of crypt invasion by <i>C</i>. <i>rodentium</i> in IFNγ^-/- mice. Data are the means with standard errors. Statistical significance was assessed utilizing the t-test. **<i>P</i><0.01; ***<i>P<</i>0.001.