miR-155^−/− mice have altered expression of inflammatory and metabolic genes in liver.

<p>(<b>A</b>) FACS quantification of the % CD45⁺F4/80⁺ macrophages in livers fed HFD and representative F4/80⁺ macrophage staining (brown) and isotype controls (inset) in liver (40x magnification, scale bar 5 µm). qRT-PCR analysis of expression of inflammatory genes (<i>Socs1, Il1b, Il6, Tnf, and Nos2</i>) (<b>B</b>), and metabolic genes (<i>Pck1, Ppargc1a, Pparg, Cebpa, Cebpb, Hmgcr, Ldlr, Srebf1, Cd36, Cyp7a1, Fas, Acc, Fabp4, Ampk, Cpt1a, Crot</i>) (<b>C</b>) relative to WT control. Data are Means ± SEM pooled from 2 independent experiments, n = 3–5 mice/group. * p<0.05, ** p<0.01 Student’s unpaired <i>t</i>-test compared to WT fed HFD.