HBV and HCV infection of mice transplanted with human hepatocytes.

<p>Mice transplanted with human hepatocytes for 8 weeks were inoculated with HBV (A) or HCV (B) human chronic carriers sera, animals were bled weekly and analyzed by PCR for the presence of HBV or HCV viral particles. In the table are indicated in the first line animal identification, with black boxes when viral genomes were detected in mice sera and the maximum human albumin concentration detected in each animal along the experiment. Viral presence was determined when the PCR reaction gave a positive result without quantifying it (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074948#pone.0074948.s001" target="_blank">Figure S7</a> in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074948#pone.0074948.s001" target="_blank">File S1</a>). In B, there are presented two independent HCV inoculation experiments.