Human immune cell infiltration and inflammation in HCV infected HIL mice.

<p>Liver sections from (A-B) mock infected or (C-F) HCV infected HIL mice 27 weeks post infection were stained for human CD45 and counterstained with haematoxylin. Representative images showing (A) liver from mock infected HIL mice, (B) high magnification of an area in mock infected mice (Squared region), (C) liver from HCV infected HIL mice, (D-E) high magnification of areas in a hepatocellular adenoma from HCV infected mice, and (F) high magnification of an area in a non-tumour region from HCV infected mice. (G-I) Representative images showing human (G) CD68, (H) CD3 and (I) CD20 stains within hepatocellular adenoma in HCV infected mice. (J-K) Plasma samples at 27–28 weeks post infection were quantified for the presence of human cytokines: (J) IL10, IL12p70, IL17A, IL23 (K) MCP-1, IL6, IL8, IL18 and IFN-γ. Mock n = 10, 10⁶ ffu HCV n = 5, 10⁷ ffu HCV n = 16.