P1736 did not adversely affect body weight in preclinical diabetic models.

<p><b>a</b>, Body weights of male <i>db/db</i> mice treated with vehicle (empty diamonds) or P1736 (150mg/kg, solid square) or metformin (solid triangle) for 15 days. Body weight was measured daily and recorded. <b>b</b>, Change in the weights of <i>db/db</i> mice treated with vehicle(empty diamonds) or P1736 (5 mg/kg twice daily, solid squares) or rosiglitazone (5 mg/kg, solid triangles) for 15 days. Data are expressed as Mean ± SEM for 7 - 10 animals per treatment group. * p< 0.05 compared to vehicle.