Combined effects of DFMO+diclofenac inhibit the growth of A431 xenograft tumors.

<p>(A) Tumor growth curve and end-point tumor volume at day 15 in A431 xenografts (n = 10) treated with DFMO and diclofenac as individual agent and in combination. @ - significant when DFMO alone compared to vehicle-treated control, # - significant when diclofenac alone compared to vehicle-treated control, $ - significant when DFMO+diclofenac compared to vehicle, & and ? - significant when DFMO+diclofenac compared to single treatment of DFMO and diclofenac respectively. All values are mean±SEM; *, p<0.05, **, p<0.005, ***, p<0.0001. (B) A431 cells (2.5×10⁶) were injected subcutaneously into the right and left flank of nude mice. Representative animal from different groups after 15 days of drug treatment compared to the vehicle-treated control. The tumors are marked in dotted red lines.