NSAIDs reduce the growth of HEY xenografts in nude mice.

<p>HEY cells (1.5×10⁶) were injected subcutaneously into both flanks of nude mice. A) Mice were randomized into 2 groups: control or diclofenac (18 mg/kg). Treatment was started three days after cell injection and was administered intraperitoneally twice a week for 4 weeks. Tumors were measured twice a week, starting at week 1. The control group (only PBS) consisted of 6 mice that developed 12 tumors in total; the diclofenac group (18 mg/kg) consisted of 6 mice that developed a total of 11 tumors. Values represent means ± standard errors. Statistical significance is represented as * p<0.05. B) Mice were randomized into 2 groups: control or indomethacin (2.5 mg/kg). Treatment was started the day after cell injection and was given daily in drinking water for 6 weeks. Tumors were measured twice a week, starting at week 3. The control group (only water) consisted of 5 mice that developed 9 tumors in total; the indomethacin group (2.5 mg/kg) consisted of 5 mice that developed a total of 5 tumors. Values represent means ± standard errors. Statistical significance is represented as * p<0.05.