The effect of STAMP2 gene overexpression on macrophages infiltration and macrophage polarization in WAT and BAT of ApoE^−/−/LDLR^−/− mice.

<p>A: Immunohistochemical staining showing accumulation of F4/80-positive, CD11c-positive and CD206-positive cells in adipose tissue (brown staining considered positive staining; scale bar: 50 µm); B: Semiquantification of F4/80 immunnohistochemical staining and analysis of the ratio of CD11c-positive cells to CD206-positive cells. Data are mean ± SEM (three sections per mice; n = 4 per group). *<i>P</i><0.05 vs. Control+vehicle; ^#<i>P</i><0.05 vs. DM+vehicle. IOD: integrated optical density; EWAT: epididymal white adipose tissue; SWAT: subcutaneous white adipose tissue; BAT: brown adipose tissue.