Magnitude of YF and Gag-specific CD8⁺ T-cell responses in animals vaccinated with YF 17DD and YF 17D recombinant viruses.

<div><p>Groups of mice (C57BL/6 strain and BALB/c strain) were immunized twice 15 days apart with vehicle medium (mock), YF vaccine (17 DD), recombinant 17 D SIV-Gag _45-269 or recombinant 17 D Δ IRES virus. Spleen cells of each mouse were recovered 14 days after second immunization and cultured with 2 μg/mL of YF CD8 specific peptides (Panel A-C) or 5 mM of SIV Gag peptide pool (Panel D-F). Results are representative of three independent experiments and are normalized to non-stimulated cells control. Bars represent the medians. Statistics were done by Mann-Whitney T test. </p> <p>* <i>p</i><0.05, ** <i>p</i><0.01, *** <i>p</i><0.001.</p>