Role of CD8⁺ T cells in mediating protection from YF viral challenge following Ad-YF NS3 vaccination.

<p>WT B6 mice, H-2K^b KO mice, β2m KO mice, IFN-γ/Prf double KO mice and MHC class II KO mice were vaccinated with Ad-YF NS3 and 14 days later intracranial challenged with YF-17D virus. <b>a)</b> Survival curves are depicted; n = 5 in WT group and 10 in all other groups. <b>b)</b> Numbers of NS3_(268–275)—specific CD8⁺ T cells in the spleen of WT B6 mice and MHC class II KO mice 8 days post Ad-YF NS3 vaccination are enumerated. Results are pooled from two independent experiments; symbols denote individual animals.