CD4⁺ and CD8⁺ T cells play important roles on the protective responses induced in mice immunized with the αDEC-NS1 mAb.

<p>Mice were immunized as described in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002330#pntd-0002330-g003" target="_blank">figure 3</a>. One day before the challenge, mice were intravenously injected with 100 µg of αCD4 or αCD8 purified antibodies to deplete the respective T cell populations. Survival (A) and morbidity (B) were monitored daily for 21 days after the challenge. n = 8 mice/group. * Refers to p<0.05 when compared to the αDEC-NS1+αCD4 mAb, adjuvant and saline groups.