Domain location and conservation of five CASK mutations.

<p><i>A.</i> Five CASK XLMR mutations are shown in reference to CASK’s domain structure. <i>B.</i> A comparison of the five mutation sites in CASK orthologs from nine species. Conserved residues, white. Residues identical to the mutation, black. Residues that differ from the wild-type and mutant hCASK sequence are gradiently shaded to indicate their similarity to the native hCASK residue.