Structural modeling of four CASK mutations.

<p>Dotted lines indicate contacts. <i>A.</i> CAMK domain of CASK (3c0i.pdb) showing R28 and Y268. <i>B.</i> Native (Arg, cyan) and mutant (Leu, magenta) side-chains at position 28. <i>C.</i> Native (Tyr, cyan) and mutant (His, magenta) side-chains at position 268. <i>D.</i> SH3-GuK domain homology model showing Y728 and W919. SH3 region, yellow. GuK region, pink. <i>E.</i> Native (Tyr, cyan) and mutant (Cys, magenta) side-chains at position 728. <i>F.</i> Native (Trp, cyan) and mutant (Arg, magenta) side-chains at position 919.