<p>The P (phosphorylation) domain, N (nucleotide binding) domain and A (actuator) domains are indicated. The transmembrane domains (M0-M10) are numbered 0-10. Relative locations of mutant alleles are indicated, including left breakpoint of <i>ok3473</i> deletion allele. Sizes of different domains are not strictly to scale.</p
<p>(A) Thin layer chromatography shows that M1 and the mutants containing M3 (M3, M23 and M13) have ...
<p>The open reading frames of the MPER display mutants contain a heterologous leader peptide (LP), a...
<p><i>TP53</i>: AD activation domain (amino acid 1–50); PD proline-rich domain (amino acid 63–97); T...
<p>Alignments were done in TCoffee <a href="http://www.plosone.org/article/info:doi/10.1371/journal....
<p>(A) Domain locations of mutations in PBP3. (B) Domain locations of mutations in PBP6. The three c...
<p>(a) Schematic depicting the germline <i>ETV6</i> mutations detected in the MSKCC and SJCRH kindre...
<p>The amino acid number was designated according to the previous nomenclature described in the Huma...
<p>Amino acids forming potential cleavage sites were replaced by alanine residues using site directe...
<p><i>A.</i> Five CASK XLMR mutations are shown in reference to CASK’s domain structure. <i>B.</i> A...
<p>Panel A: Three host range mutation hotspots (accounting for 86% of all mutations) are highlighted...
<p>a) Peripheral position of the amino acid 277 (domain A); b) Wild type variant 277Glu; c) Mutant v...
<p>Two views of HERG PAS domain structure X-ray structure (PDB code 1BYW), related by ∼180° vertical...
(A) The intron-exon structure of the gene. The novel mutations are shown in bold. (B) Different doma...
<p>Amino acid positions 294, 310, 359, 368, 373 and 396 were found to be associated with the Sydney2...
<p>Mutation sites of the amino acid residues in the six sub-clones compared to the B6 consensus sequ...
<p>(A) Thin layer chromatography shows that M1 and the mutants containing M3 (M3, M23 and M13) have ...
<p>The open reading frames of the MPER display mutants contain a heterologous leader peptide (LP), a...
<p><i>TP53</i>: AD activation domain (amino acid 1–50); PD proline-rich domain (amino acid 63–97); T...
<p>Alignments were done in TCoffee <a href="http://www.plosone.org/article/info:doi/10.1371/journal....
<p>(A) Domain locations of mutations in PBP3. (B) Domain locations of mutations in PBP6. The three c...
<p>(a) Schematic depicting the germline <i>ETV6</i> mutations detected in the MSKCC and SJCRH kindre...
<p>The amino acid number was designated according to the previous nomenclature described in the Huma...
<p>Amino acids forming potential cleavage sites were replaced by alanine residues using site directe...
<p><i>A.</i> Five CASK XLMR mutations are shown in reference to CASK’s domain structure. <i>B.</i> A...
<p>Panel A: Three host range mutation hotspots (accounting for 86% of all mutations) are highlighted...
<p>a) Peripheral position of the amino acid 277 (domain A); b) Wild type variant 277Glu; c) Mutant v...
<p>Two views of HERG PAS domain structure X-ray structure (PDB code 1BYW), related by ∼180° vertical...
(A) The intron-exon structure of the gene. The novel mutations are shown in bold. (B) Different doma...
<p>Amino acid positions 294, 310, 359, 368, 373 and 396 were found to be associated with the Sydney2...
<p>Mutation sites of the amino acid residues in the six sub-clones compared to the B6 consensus sequ...
<p>(A) Thin layer chromatography shows that M1 and the mutants containing M3 (M3, M23 and M13) have ...
<p>The open reading frames of the MPER display mutants contain a heterologous leader peptide (LP), a...
<p><i>TP53</i>: AD activation domain (amino acid 1–50); PD proline-rich domain (amino acid 63–97); T...