Inhibition of ROCK with H1152 causes relaxation of rat mesenteric collecting lymphatic vessels.

<p><i>A.</i> An example of the lymphatic diameter over time before and after treatment with increasing concentrations of the ROCK Inhibitor H1152. Lines indicate the 5-min. intervals used for the data summarized in panels <i>B</i>–<i>G</i>. H1152 significantly increased EDD/MaxD (<i>B</i>) and ESD/MaxD (<i>C</i>) when applied at concentrations of 1 and 10 μM. <i>D</i>–<i>F.</i> AMP/MaxD, lymphatic tone, and EF were all significantly decreased by 1 and 10 μM H1152. <i>G.</i> H1152 applied at 10 μM significantly decreased CF. N = 5 lymphatics from 5 different rats. *P<0.05 and **P<0.01 vs. baseline prior to H1152 addition.