Antiproteinuric intervention strongly prevents renal lymphangiogenesis.

<p>Lymphatic vessel number was significantly higher in the kidneys of proteinuric rats than in rats receiving anti-proteinuric treatment. Representative images of interstitial lymphatic vessels (arrows) in the kidney of proteinuric (A) compared to treated animals (B). Quantification showed a significant reduction of lymph vessel number upon anti-proteinuric treatment (C), whereas efficacy of ACE inhibition on proteinuria is shown in D. Dashed line shows the mean number of cortical lymphatic vessels in kidneys of healthy rats. (Bar = 100 µm, **p<0.01, ***p<0.001).