IgG antibody responses during T-705 efficacy studies in Wistar-Furth rats.

<p>Total IgG levels were measured using an indirect antigen-capture ELISA, and the data are expressed as the SumOD of each sample. The cutoff value is indicated by the horizontal dotted line, which represents 3 standard-deviations above the control wells. (A) Dose-determination study, and (B) Delayed-treatment study. For the untreated groups on each panel, serum was taken at necropsy when the rats were moribund (between 4–6 days post-infection). For the surviving rats within the T-705 treated groups (black circles), serum samples were taken at necropsy at the end of the study (day 42). Serum was available for 4 of the 6 T-705 treated rats that died (indicated by the red squares on each graph). Unpaired t-tests were used to compare each T-705 treated group with the untreated control group. Level of significance is indicated by the number of asterisks.