Cardiac autonomic response to the injection of saline.

<p>Time course of changes in heart rate (panel A), RMSSD values (panel B), high frequency (HF) spectral power (panel C) and LF to HF ratio (panel D) following the injection of saline, in Fto^+/+ (n = 8) and Fto^−/− (n = 12) mice. Baseline reference value (bas) is the mean value of the ten 3-min time points in resting conditions. Values are expressed means ± SEM. * and ^# indicate a significant difference between Fto^+/+ and Fto^−/− mice (p&lt;0.05 and p&lt;0.01, respectively).