Cardiovascular effects of adrenergic receptor blockade.

<p>Panel A shows mean values of MAP and HR during WAKE in a group of KO mice fed a HFD and subjected to pharmacological treatment with saline (vehicle, n = 5), prazosin (a α₁ adrenergic receptor blocker, n = 6) and metoprolol (a β₁ adrenergic receptor blocker, n = 5) during both the light and dark periods. Segments connect the values measured in the same mouse after drug or vehicle injection during the light (open triangles) and dark (filled triangles) periods. Values of MAP and HR after prazosin and metoprolol formed two separate clusters and are shown in black and white. Values of MAP and HR after saline are shown in red and white. Panels B and C show means and SEM of ΔMAP and ΔHR during WAKE across the light-dark transition (LDT) for the same mice in A. #, <i>P</i><0.05, vs. saline. For other abbreviations, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100536#pone-0100536-g001" target="_blank">Figure 1</a>.