The cardiovascular system of the BACHD mice responded adaptively to chronic treatment with an adrenoreceptor challenge (ISO, 0.96mg/kg per day for 30 days).

<p>Examples of ECG waveforms from WT (n = 10) (A) and BACHD (n = 8) mice (B). The ST segment range is shown by the black line. ISO increased HR (C) and elevated the ST segment voltage (D) in both genotypes indicating that the drug was effective in stimulating the heart also in BACHD mice. No significant difference in the response to ISO between genotypes was detected. ^#<i>P</i><0.05 vs. saline.