Protective effects of AS-IV on Aβ1-42-induced apoptosis in SK-N-SH cells.

<p>A. Detection of apoptosis by TUNEL assay in different groups. Percentage of TUNEL positive cells was relative to the untreated vehicle cells. ^#<i>P</i><0.01 <i>vs</i> vehicle; ^*<i>P</i><0.01 <i>vs</i> Aβ1-42 (n = 4). B. AS-IV inhibited Aβ1-42-induced activation of caspase-3 in SK-N-SH cells. A representative blots of immunoreactive bands for cleaved caspase-3 in SK-N-SH cells. C. Data were expressed as fold-increase of cleaved caspase-3 relative to vehicle. Protein expression levels were normalized to β-actin. ^#<i>P</i><0.01 <i>vs</i> vehicle; ^*<i>P</i><0.01 <i>vs</i> Aβ1-42 (n = 4).