Arsenic/IFN synergistically inhibited proliferation and induced apoptosis of ascites-derived BC3 (left) and BCBL-1 cells (right).

<p>(<b>A</b>) Cell Proliferation: Cells were plated in a 96 well format and treated with the single agent drugs or their combinations for 24, 48, and 72h. Results are expressed as percent of control, plotted as mean ± SD, and are representative of two independent experiments. (<b>B</b>) Annexin V staining: BC-3 and BCBL-1 ascites were treated for 48h. Histograms represent the proportion of apoptotic cells. Results are plotted as mean ± SD and are representative of at least 2 independent experiments. (<b>C</b>) TUNEL assay: BC-3 and BCBL-1 cells derived from PEL ascites were treated for 72h. Histograms represent apoptotic cells as percentage of the untreated controls and are plotted as mean ± SD.